Nanoencapsulation of Protein/Antibody Drugs
ANP-015 is a nanoencapsulated antibody cocktail for the treatment of Zaire Ebola virus. The naked antibody cocktail is currently the most effectivetreatment for Ebola infection under compassionate use. However, it can only be shipped and stored at -80 °C, which makes it very difficult to use in low resource areas such as West Africa. Through the utilization of our nano-drug delivery system, our nanoencapsulated antibody cocktail can be shipped and stored at room or elevated temperatures. Importantly, this technology can be applied to other large molecule based therapeutics that need better stability across a broad temperature range.
Recently, ANP Technologies®, Inc.. is working on the development and clinical testing of ANP-015. As mentioned above, this new, highly effective, and temperature stable antibody therapy for the treatment of Ebola infection will help save countless lives through its drastically improved stability.
Significantly improved stability of large molecule therapeutic proteins to allow storage at room temperature or above.
Identical efficacy to non-encapsulated antibody even after exposed to extreme heat conditions, as demonstrated by both in vitroand in vivo studies.